If you come from Rethymnon, take the main road south towards Spili and Timbaki, but branch off westward already before Spili. The first possible diversion runs via Agios Vasilios through a heathland to Agios Ioannis and from there through the Kotsifou Gorge to a lookout above the south coast. From there you can go via Sellia to Plakias, or take the eastern road over Myrthios down to Plakias.
The second possible diversion leads via Koxare through the Kourtaliotiko Gorge which is well worth seeing to Asomatos, and from there it is again two different options: either along the slope of the Kouroupa Mountains to the West through Mariou and down to Plakias, or immediately down to Lefkogia and from there westwards past Damnoni to Plakias.
If you come from Heraklion, the best is to take the highway to Rethymnon and from there the country road to the South. But there is also a fourth alternative, which however requires much more time:
You can also take the road from Heraklion via Agia Varvara to the South and then cross the Messara Plain from Agii Deka via Mires and Timbaki to the West. Then you pass Agia Galini, and afterwards you can go via Saktouria to Agios Pavlos. From there it is a bumpy dirt road along the coast to the West, and passing the beaches of Agia Paraskevi, Triopetra and Ligres you will come to Preveli, from where you come via Lefkogia to Plakias.
However, this route is almost a day trip, and it also suits for those holidaymakers who explored the south coast of Crete already once before.
So far about the manifold options if you take a car at the airport
for your holiday in Plakias
. For more about Plakias, see http://www.plakias.cretanet.com